Publications

Evolved Aztreonam Resistance Is Multifactorial and Can Produce Hypervirulence in Pseudomonas aeruginosa. Jorth P, McLean K, Ratjen A, Secor PR, Bautista GE, Ravishankar S, Rezayat A, Garudathri J, Harrison JJ, Harwood RA, Penewit K, Waalkes A, Singh PK, Salipante SJ. MBio. 2017 Oct 31;8(5). pii: e00517-17. doi: 10.1128/mBio.00517-17. PMID: 29089424

Restoring Cystic Fibrosis Transmembrane Conductance Regulator Function Reduces Airway Bacteria and Inflammation in People with Cystic Fibrosis and Chronic Lung Infections. Hisert KB, Heltshe SL, Pope C, Jorth P, Wu X, Edwards RM, Radey M, Accurso FJ, Wolter DJ, Cooke G, Adam RJ, Carter S, Grogan B, Launspach JL, Donnelly SC, Gallagher CG, Bruce JE, Stoltz DA, Welsh MJ, Hoffman LR, McKone EF, Singh PK. Am J Respir Crit Care Med. 2017 Jun 15;195(12):1617-1628. doi: 10.1164/rccm.201609-1954OC. PMID: 28222269

Microbial Community Composition Impacts Pathogen Iron Availability during Polymicrobial Infection. Stacy A, Abraham N, Jorth P, Whiteley M. PLoS Pathog. 2016 Dec 14;12(12):e1006084. doi: 10.1371/journal.ppat.1006084. eCollection 2016 Dec. PMID: 27973608

Next-Generation "-omics" Approaches Reveal a Massive Alteration of Host RNA Metabolism during Bacteriophage Infection of Pseudomonas aeruginosa. Chevallereau A, Blasdel BG, De Smet J, Monot M, Zimmermann M, Kogadeeva M, Sauer U, Jorth P, Whiteley M, Debarbieux L, Lavigne R. PLoS Genet. 2016 Jul 5;12(7):e1006134. doi: 10.1371/journal.pgen.1006134. eCollection 2016 Jul. PMID: 27380413

Regional Isolation Drives Bacterial Diversification within Cystic Fibrosis Lungs. Jorth P, Staudinger BJ, Wu X, Hisert KB, Hayden H, Garudathri J, Harding CL, Radey MC, Rezayat A, Bautista G, Berrington WR, Goddard AF, Zheng C, Angermeyer A, Brittnacher MJ, Kitzman J, Shendure J, Fligner CL, Mittler J, Aitken ML, Manoil C, Bruce JE, Yahr TL, Singh PK. Cell Host Microbe. 2015 Sep 9;18(3):307-19. doi: 10.1016/j.chom.2015.07.006. Epub 2015 Aug 20. PMID: 26299432

Bacterial fight-and-flight responses enhance virulence in a polymicrobial infection. Stacy A, Everett J, Jorth P, Trivedi U, Rumbaugh KP, Whiteley M. Proc Natl Acad Sci U S A. 2014 May 27;111(21):7819-24. doi: 10.1073/pnas.1400586111. Epub 2014 May 13. PMID: 24825893

Metatranscriptomics of the human oral microbiome during health and disease. Jorth P, Turner KH, Gumus P, Nizam N, Buduneli N, Whiteley M. MBio. 2014 Apr 1;5(2):e01012-14. doi: 10.1128/mBio.01012-14. PMID: 24692635

Probing bacterial metabolism during infection using high-resolution transcriptomics. Jorth P, Trivedi U, Rumbaugh K, Whiteley M. J Bacteriol. 2013 Nov;195(22):4991-8. doi: 10.1128/JB.00875-13. Epub 2013 Aug 23. PMID: 23974023

The role of two Pseudomonas aeruginosa anthranilate synthases in tryptophan and quorum signal production. Palmer GC, Jorth PA, Whiteley M. Microbiology. 2013 May;159(Pt 5):959-69. doi: 10.1099/mic.0.063065-0. Epub 2013 Feb 28. PMID: 23449919

An evolutionary link between natural transformation and CRISPR adaptive immunity. Jorth P, Whiteley M. MBio. 2012 Nov 1;3(5). pii: e00309-12. doi: 10.1128/mBio.00309-12. Print 2012. PMID: 23033473

Characterization of a novel riboswitch-regulated lysine transporter in Aggregatibacter actinomycetemcomitans. Jorth P, Whiteley M. J Bacteriol. 2010 Dec;192(23):6240-50. doi: 10.1128/JB.00935-10. Epub 2010 Oct 1. PMID: 20889741

Characterization of the Pseudomonas aeruginosa transcriptional response to phenylalanine and tyrosine. Palmer GC, Palmer KL, Jorth PA, Whiteley M. J Bacteriol. 2010 Jun;192(11):2722-8. doi: 10.1128/JB.00112-10. Epub 2010 Mar 19. PMID: 20304990

Characterization of alanine catabolism in Pseudomonas aeruginosa and its importance for proliferation in vivo. Boulette ML, Baynham PJ, Jorth PA, Kukavica-Ibrulj I, Longoria A, Barrera K, Levesque RC, Whiteley M. J Bacteriol. 2009 Oct;191(20):6329-34. doi: 10.1128/JB.00817-09. Epub 2009 Aug 7. PMID: 19666712

Identification of immunologic and pathologic parameters of death versus survival in respiratory tularemia. Chiavolini D, Alroy J, King CA, Jorth P, Weir S, Madico G, Murphy JR, Wetzler LM. Infect Immun. 2008 Feb;76(2):486-96. Epub 2007 Nov 19. PMID: 18025095